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| 1951 |
| | Syntex, a small chemical company in Mexico City, develops the first oral contraceptive | |
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| 1956 |
| | Communist activist Fidel Castro returns from Mexico to Cuba to organize guerrilla warfare against the Batista regime | |
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| 1957 |
| | Jack Kerouac publishes a largely autobiographical novel, On the Road, describing his experiences travelling through the US and Mexico | |
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| 1960 |
| | 20-year-old Spanish tenor Placido Domingo sings his first major role, as Alfredo in La Traviata in the Mexican city of Monterrey | |
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| 1992 |
| | All the Pretty Horses is the first volume of US author Cormac McCarthy's trilogy set in Mexico | |
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| 1994 |
| | Mayan Indians in Chiapas rebel in an armed uprising against the Mexican government | |
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| 1994 |
| | Two leading members of Mexico's ruling party, Luis Donaldo Colosio and José Francisco Ruiz Massieu, are assassinated | |
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| 1994 |
| | A devaluation of the Mexican peso leads to a sudden collapse in the local stock market | |
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| 1997 |
| | Mexico's ruling party, the PRI, loses control of the lower house for the first time in nearly seventy years | |
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| 2000 |
| | Vicente Fox wins the presidential election in Mexico (the first time that an opposition politician has done so since 1911) | |
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